3D skin made of stem cells treats backbone birth defect in rodents
This picture exhibits iSkin (three-dimensional cultured pores and skin) derived from human iPSCs. Immunohistochemical evaluation with antibodies to KERATIN 14 (KRT14), p63, cytokeratins (Pan-CK), involucrin, laminin 5, loricrin, KRT10, and filaggrin. The multilayered dermis expressed KRT14, involucrin, laminin 5, Pan-CK, loricrin, KRT10, and filaggrin in iSkin, indicating that iPSC-keratinocytes terminally differentiate within the pores and skin equivalents. Scale bar is 100 ?m. Credit score: Kazuhiro Kajiwara Myelomeningocele is a extreme congenital defect during which the spine and spinal canal don't shut earlier than start, placing these affected vulnerable to lifelong neurological issues. In a preclinical research printed June sixth in Stem Cell Reviews , researchers developed a stem cell-based remedy for producing pores and skin grafts to cowl myelomeningocele defects earlier than start. They first generated synthetic pores and skin from ...